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Indication & Dosage |
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| Oral |
| DIARRHOEA IN INFANTS AND CHILD CAUSED BY E.COLI, SAMONELLA AND SHIGELLA |
| Adult:
(Met 500mg + Nor 400mg): 1 tab b.i.d. (Met 100mg + Nor 100mg) syrup: 5-10ml b.i.d. |
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| Precautions |
Pregnancy, lactation renal/hepatic impairment. H/O convulsions. Ensure adequate hydration, urinary output. Patients predisposed to seizures. |
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Potentially Life-threatening
Adverse Drug Reactions |
Peripheral neuropathies. GI disturbances, rash, urticaria, pruritus, superinfection (candida), metallic taste, headache, dizziness, transient leucopaenia, paraesthesias, tongue, glossitis, pseudomembranous colitis (rare). Reduced serum levels of cholesterol, and triglycerides, nausea, vomiting, heart burn, constipation/diarrhoea, headache, dizziness, depression, insomnia, dry mouth, fever, arthralgia and anaemia. Elevated liver enzymes, urea and creatinine. |
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| Adverse Drug Reactions |
Seizures, eosinophilia, neutropaenia, thrombocytopaenia. |
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| Interactions |
Acute psychoses when metronidazole co-administered with disulfiram. It has additive/synergistic effect with other antimicrobials. Blood levels increased by cimetidine. Antacids reduce absorption of norfloxacin from GIT. |
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